Effect of Intravenous Pyridoxine on Control of Vomiting Due to Gastroenteritis in Children Aged between ۶ Months and ۱۲ Years

Abstract

Background &Objectives: Antiemetic drugs can be used in complicated cases of vomiting
secondary to gastroenteritis. There is no previous study dealing with the use of pyridoxine in
treatment of vomiting in pediatrics. This Studyintendsto review the effects of intravenous
pyridoxine on control of gastroenteritis related vomiting.
Methods: This study is a single blind randomized clinical trial with placebo. A total number of
147 children diagnosed with gastroenteritis induced vomiting and admitted in Amirkabir hospital
from August to December 2011 were studied and divided to two case andcontrol groups. In the
control group intravenous fluid with distilled water (placebo) was used and the pyridoxine was
given along with intravenous fluid therapy in case group. Since admission for three days, numbers
of vomiting and other symptoms were collected in data form. Results were analyzed using SPSS-
16 by means of descriptive analysis for basic information.
Results: Most children were male, aged between 6 months and 2 years and having urban life.
There was no significant difference between two groups in the mean of vomiting frequency during
the period of hospitalization (p>0.05).There was also no significant difference between two groups in
duration of hospitalization (p=0.19).
Conclusion: Based on this study pyridoxine (Vitamin B6) was not effective in treatment of
vomiting due to gastroenteritis in children, and did not reduce the duration of hospitalization.
Key words: Gastroenteritis; Vomiting; Pyridoxine